Hepatitis C

TABLE OF CONTENTS

Hepatitis C

Treatments

Non-drug

Prescription Drugs

Harvoni (Ledipasvir/sofosbuvir) Olysio (Simeprevir) Sovaldi (Sofosbuvir) Viekira Pak (Ombitasvir/paritaprevir/ritonavir; Dasabuvir)

Over-the-counter Drugs

What Leading Medical Organizations Recommend When Treating Hepatitis C

WHAT TO TRY FIRST

The Infectious Diseases Society of America Guidelines recommend the following treatments for people who are being treated for the first time.  Unless a treatment is listed as an alternative, the Society felt that all the treatments worked equally well.

  • For Hepatitis C genotype 1a Daclatasvir/Sofosburiv for 12 weeks (no cirrhosis) or 24 weeks with or without ribavirin (cirrhosis); Ledipasivir/Sofosbuvir for 12 weeks; Paritaprevir/Ritonavir/Ombitasvir + Dasabuvir and ribavirin for 12 weeks (no cirrhosis) or 24 weeks (cirrhosis); Simeprevir/Sofosburvir with or without ribavirin for 12 weeks (no cirrhosis) or 24 weeks (cirrhosis without Q80K polymorphism).
  • For Hepatitis C genotype 1b  Daclatasvir/Sofosburiv for 12 weeks (no cirrhosis) or 24 weeks with or without ribavirin (cirrhosis); Ledipasivir/Sofosbuvir for 12 weeks; Paritaprevir/Ritonavir/Ombitasvir + Dasabuvir and ribavirin for 12 weeks; Simeprevir/Sofosburvir for 12 weeks (no cirrhosis) or 24 weeks with or without ribavirin (cirrhosis).
  • For Hepatitis C genotype 2  Daclatasvir/Sofosburiv for 12 weeks for people who cannot take ribavirin (cirrhosis); Sofosbuvir and ribavirin for 12 weeks (no cirrhosis) or 16 weeks (cirrhosis).
  • For Hepatitis C genotype 3  Sofosbuvir + ribavirin + peg-interferon for 12 weeks or Sofosbuvir + ribavirin for 12 weeks for people who cannot take interferon
  • For Hepatitis C genotype 4  Ledipasivir/Sofosbuvir for 12 weeks; Paritaprevir/Ritonavir/Ombitasvir + Dasabuvir and ribavirin for 12 weeks, Sofosbuvir + ribavirin for 24 weeks or Sofosbuvir + ribavirin + peg-interferon for 12 weeks
  • For Hepatitis C genotype 5 or 6  Ledipasivir/Sofosbuvir for 12 weeks; Sofosbuvir + ribavirin for 12 weeks is an acceptable alternative

WHAT ELSE TO TRY

Different treatments are recommended for people whose Hepatitis C failed to respond to other drugs. 

SOURCE

Infectious Diseases Society of America and the American Association for the Study of Liver DiseasesHCV Guidance: Recommendations for testing, managing and treating Hepatitis C - Initial Treatment Box. Published August 2015.