Altoprev

Lovastatin

For High Cholesterol

Track record

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Long (approved in 2002)

Bottom line

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High Cholesterol

What is High Cholesterol?

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Other treatments for High Cholesterol

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Non-drug

Over-the-counter

Prescription

TABLE OF CONTENTS

Overview

FDA-approved use

To lower cholesterol to reduce the chance of having a first heart attack or stroke in adults at increased risk

Altoprev, long-acting mevacor, is a statin. All major medical organizations suggest considering drugs in the statin family - not just Altoprev - to reduce the chance of a first heart attack or stroke in adults at increased risk. FDA officially approved Altoprev to reduce the chance of having a heart attack, threatened heart attack (unstable angina) and procedures to unblock arteries in the heart in people without heart disease or a stroke with at least 1 risk factor: low levels of "good cholesterol" (HDL), high blood pressure, family history of heart attack at a young age, smoking or diabetes. FDA also approved Altoprev to lower LDL "bad" cholesterol, raise HDL "good" cholesterol, and lower triglycerides in adults with abnormal cholesterol levels from a genetic condition.

Who might consider taking it?

Adults without heart disease or a stroke but at increased risk

The American Heart Association suggests people consider a statin if their chance of heart attack or stroke over the next 10 years is more than 5%, and to take one if the chance is 7.5% or more. You can calculate your risk at: http://tinyurl.com/pyv57ne.

What is not known

Not tested in children

Not tested in people with Fredrickson Type I, III, and V dyslipidemias

Track record

LONG TRACK RECORD

Long track record means that new‚ unexpected side effects are unlikely. Altoprev was approved by FDA in 2002. Since Altoprev has now been used by large numbers of people over a long time‚ the emergence of important side effects is less likely than with new drugs.

Open questions

No FDA-required studies at approval

Do not take if you...

Take drugs in the family called "strong CYP3A inhibitors"

Such as ketoconazole, itraconazole, posaconazole, voriconazole, clarithromycin, telithromycin, HIV protease inhibitors, boceprevir, telaprevir, and nefazodone

Take erythromycin

Are allergic to Altoprev or its ingredients

Have liver disease

Including people who have unexplained high liver inflammation blood tests

Are pregnant or may become pregnant

Altoprev may harm your unborn baby. If you become pregnant, stop taking Altoprev

Are breastfeeding

Safe if pregnant or breastfeeding?

Pregnant

Do not take: Controlled human studies show Altoprev harms baby and potential benefits do not outweigh potential harms (FDA Category X)

Breastfeeding

Do not breastfeed - Altoprev may get into breast milk and harm baby

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