Crestor

Rosuvastatin

For High Cholesterol

Track record

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Long (approved in 2010)

Bottom line

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High Cholesterol

What is High Cholesterol?

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Other treatments for High Cholesterol

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Non-drug

Over-the-counter

Prescription

TABLE OF CONTENTS

Overview

FDA-approved use

To lower cholesterol to reduce the chance of having a first heart attack or stroke in adults at increased risk

Crestor is a statin. All major medical organizations suggest considering drugs in the statin family - not just Crestor - to reduce the chance of a first heart attack or stroke in adults at increased risk. FDA officially approved Crestor to reduce the chance of heart attack, stroke or procedures to unblock arteries in heart or legs in people with high cholesterol without heart disease or a stroke, but at increased risk because they are: men age 50 or older, women age 60 or older, have C-reactive protein (CRP) over 2 mg/L and have at least 1 other factor such as high blood pressure, low "good" cholesterol (HDL), smoking or family history of heart disease in middle age or younger. FDA also approved Crestor to slow the buildup of fatty deposits (plaque) in blood vessel walls and to lower LDL "bad" cholesterol, raise HDL "good" cholesterol, and lower triglycerides in adults and children 8 years and older with abnormal cholesterol levels from a genetic condition.

Who might consider taking it?

Adults without heart disease or a stroke but at increased risk

The American Heart Association suggests people consider a statin if their chance of heart attack or stroke over the next 10 years is more than 5%, and to take one if the chance is 7.5% or more. You can calculate your risk at: http://tinyurl.com/pyv57ne.

What is not known

Not tested in people with Fredrickson Type I and V dyslipidemias

Not tested in children with heterozygous familial high cholesterol younger than age 8

Track record

LONG TRACK RECORD

Long track record means that new‚ unexpected side effects are unlikely. Crestor was approved by FDA in 2003 to lower cholesterol and in 2010 for reducing the chance heart attack or stroke. Since Crestor has now been used by large numbers of people over a long time‚ the emergence of important side effects is less likely than with new drugs.

Open questions

No FDA-required studies at approval

Do not take if you...

Are allergic to Crestor or its ingredients

Have liver disease

Including people who have unexplained high liver inflammation blood tests

Are pregnant or may become pregnant

Crestor may harm your unborn baby. If you become pregnant, stop taking Crestor.

Are breastfeeding

Safe if pregnant or breastfeeding?

Pregnant

Do not take: Controlled human studies show Crestor harms baby and potential benefits do not outweigh potential harms (FDA Category X)

Breastfeeding

Do not breastfeed while taking Crestor - either stop breastfeeding or stop Crestor

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