In type 2 diabetes, the pancreas produces enough insulin, at least in the early years of the disease. But for reasons that are still not well understood, the body’s cells become resistant or insensitive to it. As a result, the telltale marker — and problem — of diabetes emerges: glucose levels rise in the blood because it is unable to enter the body’s cells. The excess glucose is damaging to the body’s tissue and leads to the symptoms and complications of diabetes.
To help control blood sugar in adults and children age 10-16 with type 2 diabetes
Who might consider taking it?
Adults and children age 10-16 with type 2 diabetes whose blood sugar is not controlled by diet and exercise. Glucophage is NOT for treatment of type 1 diabetes or diabetic ketoacidosis.
What is not known
There is no evidence that Glucophage reduces your chance of stroke, heart attack or vascular disease
Not tested in children less than 10 years
How Glucophage affects babies during pregnancy is unknown
LONG TRACK RECORD
Long track record means that new, unexpected side effects are unlikely. Glucophage was approved by FDA in 1995. Since Glucophage has now been used by large numbers of people over a long time, the emergence of rare but serious side effects is less likely than with new drugs.
No FDA-required studies at approval
Do not take if you...
Are allergic to metformin
Have kidney disease or reduced kidney function on blood tests
Blood creatinine level 1.5 or higher (men), 1.4 or higher (women)
Have diabetic ketoacidosis (increased ketones in blood or urine)
Are 80 years or older and have NOT had your kidney function tested
Glucophage can be dangerous if kidney function is reduced. Need to make sure kidney function is okay before starting.
Have type 1 diabetes
Not recommended if you...
Have liver disease
Have dangerously low blood pressure from a new heart attack, heart failure or other heart problem
Drink alcohol very often or drink a lot of alcohol in a short-time "binge" drinking
Alcohol can increase the chance of dangerous acid build-up (lactic acidosis)
Are younger than 10 years
Not tested so benefits and side effects are unknown
Safe if pregnant or breastfeeding?
No evidence that Glucophage harms baby (FDA Category B - second safest rating)
Do not breastfeed while taking Glucophage - either stop breastfeeding or stop Glucophage
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