Zetia

Ezetimibe

For High Cholesterol

Track record

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Long (approved in 2002)

Bottom line

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High Cholesterol

What is High Cholesterol?

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Other treatments for High Cholesterol

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Non-drug

Over-the-counter

Prescription

TABLE OF CONTENTS

Overview

FDA-approved use

To lower LDL "bad" cholesterol. Zetia has not been proven to reduce heart attacks or strokes.

Zetia can be used alone or in combination with a statin or fenofibrate. FDA officially approved Zetia to lower LDL "bad" cholesterol from a genetic condition.

Who might consider taking it?

Adults with high "bad" (LDL) cholesterol

Genetic conditions include primary hypercholesterolemia (heterozygous familial and nonfamilial), mixed hyperlipidemia and homozygous familial hypercholesterolemia (HoFH)

What is not known

Not studied in children younger than age 10 or in girls who have not started their period

Not studied in people with Fredrickson Types I, III, IV, and V dyslipidemias

Track record

LONG TRACK RECORD

Long track record means that new‚ unexpected side effects are unlikely. Zetia was approved by FDA in 2002. Since Zetia has now been used by large numbers of people over a long time‚ the emergence of important side effects is less likely than with new drugs.

Open questions

FDA-required studies at approval to answer questions about benefit and harms

The drug company was required to conduct additional studies about the benefits and side effects in non-white patients.

Do not take if you...

Are allergic to Zetia or its ingredients

Do not take Zetia with a statin if you...

Have active liver disease, are pregnant or may become pregnant, or are breastfeeding

Safe if pregnant or breastfeeding?

Pregnant

Only take if potential benefits outweigh potential harm to baby (FDA Category C)

Breastfeeding

Be cautious about breastfeeding - unknown if Zetia gets into breast milk

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